Image sequence and Spritesheets only have one thing in common. Either of them is graphical file in some format (png, jpg, tif, gif, etc).
For the rest they differ in following.
0. Images sequence (as output from Pencil) is the set of n files, where each one is one frame of animation.
1. Spritesheet is collection of usually similar in size images in one file. It could be animation, or image data for terrain tiles, or graphics for your game items.
From a programming perspective they differ in nearly same way.
0. For images sequence you must use as many sf::Textures as you have files. E.g. If you have 10 frames (10 files), then you need ten sf::Texture variables (or one vector of 10 sf::Textures) to hold image data.
1. For spritesheets you declare and define one sf::Textire variable and use different offset of TextureCoordinates to draw a sprite.
Hope this clarify things a bit.